PatentsPatent Certificate
Substance patent
New benzamide derivatives and uses thereof
Application date 2012.11.29
Priority date 2011.11.29
| ROK | Reg | 10-1542939 | 2015.08.03 |
|---|---|---|---|
| USA | Reg | 9,359,346 | 2016.06.07 |
| China | Reg | ZL201280058674.6 | 2017.03.29 |
| EU | Reg | 2786986 | 2018.02.28 |
| Japan | Reg | 6,145,109 | 2017.05.19 |
| INDIA | App | 4074 | CHENP |
Composition patent
Combination of active substances that induce a synergistic effect of multi-targeting and uses thereof
Application date 2012.06.28
Priority date 2011.06.28
| ROK | Reg | 10–1728449 | 2017.04.13 |
|---|---|---|---|
| Japan | Reg | 5,893,135 | 2016.03.04 |
| EU | App | 12 803 876.7 | 2012.06.28 |
Use patent
Method of Preventing or Treating Post Operation Pain
Application date 2020.06.19
| PCT | App | KR2020/007946 | - |
|---|
Publications
| Title | Author | Jounal | Date | Link |
|---|---|---|---|---|
| A series of case studies: Practical methodology for identifying antinociceptive multi-target drugs | Pang, M., Kim, Y., Jung, K. W., Cho, S., & Lee, D. H. | Drug Discovery Today, 17(9-10), 425-434. doi:10.1016/j.drudis.2012.01.003 | 2012 | Go to link |
| Randomised, double-blind, parallel group, placebo-controlled study to evaluate the analgesic efficacy and safety of VVZ-149 injections for postoperative pain following laparoscopic colorectal surgery | Nedeljkovic, S. S., Correll, D. J., Bao, X., Zamor, N., Zeballos, J. L., Zhang, Y., …Lee, D. H. | BMJ Open, 7(2). doi:10.1136/bmjopen-2016-011035 | 2017 | Go to link |
| Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study | Oh, J., Lee, S., Kim, A., Yoon, J., Jang, K., Lee, D. H., … Chung, J. | The Journal of Clinical Pharmacology, 58(1), 64-73. doi:10.1002/jcph.973 | 2017 | Go to link |
| Assessment of blinding in a randomized, double-blind, parallel group, placebo-controlled study to evaluate the analgesic efficacy and safety of VVZ-149 injections for post-operative pain following laparoscopic colorectal surgery | Bhandari, A., Nedelkovic, S., Bao, X., Zeballos, J., Zhang, Y., Correll, D., . . . Lee, D. | The Journal of Pain, 18(4). doi:10.1016/j.jpain.2017.02.360 | 2017 | Go to link |
| Infusion of VVZ-149 for postoperative pain following colorectal surgery is associated with high levels of patient satisfaction | Zeballos, J., Nedeljkovic, S., Bao, X., Zhang, Y., Correll, D., Young, M., . . . Lee, D | The Journal of Pain, 18(4). doi:10.1016/j.jpain.2017.02.361 | 2017 | Go to link |
| The safety of VVZ-149 injections for post-operative pain, following laparoscopic colorectal surgery | Greschler, D., Nedeljkovic, S., Bao, X., Zeballos, J., Zhang, Y., Correll, D., . . . Lee, D. | The Journal of Pain, 18(4). doi:10.1016/j.jpain.2017.02.362 | 2017 | Go to link |
| Role of VVZ-149, a Novel Analgesic Molecule, in the Affective Component of Pain: Results from an Exploratory Proof-of-Concept Study of Postoperative Pain following Laparoscopic and Robotic-Laparoscopic Gastrectomy | Song, I. S., Cho, S. R., Nedeljkovic, S. J., Lee, S. U., Lee, C. U., Kim, J. U., & Bai, S. U. | Pain Medicine. doi:10.1093/pm/pnab066 | 2021 | Go to link |
| Title | A series of case studies: Practical methodology for identifying antinociceptive multi-target drugs |
|---|---|
| Author | Pang, M., Kim, Y., Jung, K. W., Cho, S., & Lee, D. H. |
| Jounal | Drug Discovery Today, 17(9-10), 425-434. doi:10.1016/j.drudis.2012.01.003 |
| Title | Randomised, double-blind, parallel group, placebo-controlled study to evaluate the analgesic efficacy and safety of VVZ-149 injections for postoperative pain following laparoscopic colorectal surgery |
|---|---|
| Author | Nedeljkovic, S. S., Correll, D. J., Bao, X., Zamor, N., Zeballos, J. L., Zhang, Y., …Lee, D. H. |
| Jounal | BMJ Open, 7(2). doi:10.1136 / bmjopen-2016-011035 |
| Title | Safety, Tolerability, and Pharmacokinetic Characteristics of a Novel Nonopioid Analgesic, VVZ-149 Injections in Healthy Volunteers: A First-in-Class, First-in-Human Study |
|---|---|
| Author | Oh, J., Lee, S., Kim, A., Yoon, J., Jang, K., Lee, D. H., … Chung, J. |
| Jounal | The Journal of Clinical Pharmacology, 58(1), 64-73. doi:10.1002/jcph.973 |
| Title | Assessment of blinding in a randomized, double-blind, parallel group, placebo-controlled study to evaluate the analgesic efficacy and safety of VVZ-149 injections for post-operative pain following laparoscopic colorectal surgery |
|---|---|
| Author | Bhandari, A., Nedelkovic, S., Bao, X., Zeballos, J., Zhang, Y., Correll, D., . . . Lee, D. |
| Jounal | The Journal of Pain, 18(4). doi:10.1016/j.jpain.2017.02.360 |
| Title | Infusion of VVZ-149 for postoperative pain following colorectal surgery is associated with high levels of patient satisfaction |
|---|---|
| Author | Zeballos, J., Nedeljkovic, S., Bao, X., Zhang, Y., Correll, D., Young, M., . . . Lee, D |
| Jounal | The Journal of Pain, 18(4). doi:10.1016/j.jpain.2017.02.361 |
| Title | The safety of VVZ-149 injections for post-operative pain, following laparoscopic colorectal surgery |
|---|---|
| Author | Greschler, D., Nedeljkovic, S., Bao, X., Zeballos, J., Zhang, Y., Correll, D., . . . Lee, D. |
| Jounal | The Journal of Pain, 18(4). doi:10.1016/j.jpain.2017.02.362 |
| Title | Role of VVZ-149, a Novel Analgesic Molecule, in the Affective Component of Pain: Results from an Exploratory Proof-of-Concept Study of Postoperative Pain following Laparoscopic and Robotic-Laparoscopic Gastrectomy |
|---|---|
| Author | Song, I. S., Cho, S. R., Nedeljkovic, S. J., Lee, S. U., Lee, C. U., Kim, J. U., & Bai, S. U. |
| Jounal | Pain Medicine. doi:10.1093/pm/pnab066 |
Grants
| Duration | Business | Task | Organization | Remarks |
|---|---|---|---|---|
| 2011~2012 | Start-up growth technology development project | Development of tissue test-based technology for screening new drug candidates for pain treatment | Small and Medium Business Administration | - |
| 2012 | IP R&D Patent Strategy Support Project | Development of non-narcotic multi-target analgesic VVZ-149 for postoperative pain treatment (patent strategy support project) |
Korean Intellectual Property Office |
- |
| 2011~2013 | Innovative drug development non-clinical task | Development of non-narcotic multi-target analgesic VVZ-149 for postoperative pain treatment | Ministry of Health and Welfare | Selected as best project |
| 2013~2015 | Innovative drug development phase 1 clinical project | Phase 1 clinical development of non-narcotic multi-target analgesic VVZ-149 for postoperative pain treatment | Ministry of Health and Welfare | Selected as best project |
| 2015~2018 | Innovative drug development global phase 2 clinical project | Development of global phase 2 clinical trial for postoperative pain treatment for non-narcotic analgesic VVZ-149 | Ministry of Health and Welfare | Selected as best project / 2019 Ministry of Health and Welfare selected for outstanding performance |
| 2015~2016 | New drug development project for all departments | Development of oral drug VVZ-149, a clinical substance for non-narcotic acute and chronic pain inhibitors | Korean Drug Development Fund |
- |
| 2021 | Designated as an excellent enterprise research institute | Medical Biology Research Institute affiliated with Vivozon | Ministry of Science and ICT | - |
| Duration | 2011~2012 |
|---|---|
| Business | Start-up growth technology development project |
| Task | Development of tissue test-based technology for screening new drug candidates for pain treatment |
| Organization | Small and Medium Business Administration |
| Remarks | - |
| Duration | 2012 |
|---|---|
| Business | IP R&D Patent Strategy Support Project |
| Task | Development of non-narcotic multi-target analgesic VVZ-149 for postoperative pain treatment (patent strategy support project) |
| Organization | Korean Intellectual Property Office |
| Remarks | - |
| Duration | 2011~2013 |
|---|---|
| Business | Innovative drug development non-clinical task |
| Task | Development of non-narcotic multi-target analgesic VVZ-149 for postoperative pain treatment |
| Organization | Ministry of Health and Welfare |
| Remarks | Selected as best project |
| Duration | 2013~2015 |
|---|---|
| Business | Innovative drug development phase 1 clinical project |
| Task | Phase 1 clinical development of non-narcotic multi-target analgesic VVZ-149 for postoperative pain treatment |
| Organization | Ministry of Health and Welfare |
| Remarks | Selected as best project |
| Duration | 2015~2018 |
|---|---|
| Business | Innovative drug development global phase 2 clinical project |
| Task | Development of global phase 2 clinical trial for postoperative pain treatment for non-narcotic analgesic VVZ-149 |
| Organization | Ministry of Health and Welfare |
| Remarks | Selected as best project / 2019 Ministry of Health and Welfare selected for outstanding performance |
| Duration | 2015~2016 |
|---|---|
| Business | New drug development project for all departments |
| Task | Development of oral drug VVZ-149, a clinical substance for non-narcotic acute and cKorean Drug Development Fundhronic pain inhibitors |
| Organization | Korean Drug Development Fund |
| Remarks | - |
| Duration | 2021 |
|---|---|
| Business | Designated as an excellent enterprise research institute |
| Task | Medical Biology Research Institute affiliated with Vivozon |
| Organization | Ministry of Science and ICT |
| Remarks | - |
